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NAL Captive DDS Technologies |
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Bio-FX Fast-Onset Oral Cavity DDS |
Bio-FX Fast-Onset Delivery of Bioactive Drugs |
| Oral Drugs
ODT, Capsule or Tablet
absorbed via GI Tract |
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Orally Dissolving Film (“ODF”)
Drug absorption via Oral Cavity
in 10 to 30 Minutes
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Buccal Delivery System
Dental Delivery System
Sublingual Delivery System
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Examples:
Anti-Acute Severe Pain ODF
Anti-Mucositis ODF
Anti-Migraine Headache ODF
Anti-ADHD ODF
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A Novel Dosage Form:
Orally Dissolving Film (“ODF”) |
| The Bio-FX DDS is designed as an orally dissolving film (“ODF”) for sublingual or buccal delivery in the oral cavity with an apparent onset time of 5 to 30 minutes. In principle, the ODF contains the active ingredient, Bio-FX absorption enhancers, and bioadhesional polymers. |
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| Major Advantages |
Delivery Systems |
● Fast Onset
● Avoid First-Pass Liver Metabolism
● Avoid GI Degradation
● Improve Bioavailability
● Bio-FX Enhanced Oral Cavity Absorption
● Take Without Liquids |
● Sublingual
● Buccal
● Dental
● Lingual |
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Drug Plasma Concentration Profiles Observed for
NAL1239 Fentanyl Orally Dissolving Film (ODF) |
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NAL1239 Fentanyl Citrate ODF
Fentanyl is formulated in an ODF for sublingual or buccal delivery with a fast
onset time of 10 to 15 minutes for cancer patients with breakthrough pain. |
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